Environmental Sanitation
 

We live in an environment that is full of living organisms and bacteria are an essential part of that environment.  Bacteria are ubiquitous in nature and they play important role in maintaining life on this planet, so much that without bacteria, life would not be possible on Earth.  We are beginning to increasingly appreciate the value of having good bacteria in our environment, as demonstrated by increasing demand for healthy foods such as yogurts and vegetable or fruit juices that are supplemented with "good" bacteria which help us to digest various foods, synthesize some important nutrients, enhance immune system function, etc.  However, along with good bacteria, the environment also contains bacteria that are pathogenic for humans and can cause human morbidity or even mortality.  A prime example of such bacteria is Listeria monocytogenes, which occasionally makes it into food processing facilities and contaminates foods, including ready-to-eat foods.  When those foods are consumed by humans, listeriosis may ensue and the outcome of the disease can be devastating, especially in pregnant women or the elderly.  Thus, various sanitizing or disinfecting chemicals are routinely used in food processing facilities to kill L. monocytogenes and other pathogenic bacteria.  However, while those chemicals do effectively kill bacteria short term, they tend to kill all bacteria (pathogenic and beneficial) thus creating "sterile environment."  However, sterile environment is unsustainable in food processing facilities, and they rapidly become repopulated by bacteria, including pathogenic species that were the targets of original sanitation.  It is thus important to have a modality that will not attempt to sterilize the environment (a futile efforts by all means), but will rather target specifically "bad" bacteria in that environment, without disturbing the "good" bacteria.  The goal is to have environment that is colonized by "good" bacteria in which "bad" bacteria will have difficulty establishing themselves.  However, this is easier said than done, because none of the currently available chemical sanitizers or disinfectants can differentiate among "good" and "bad" bacteria.   

Bacteriophages are nature’s way to control the levels of specific bacteria in the environment.  There are bacteriophages that kill "bad" bacteria and that kill "good" bacteria - which ensures that important ecological balance can be maintained in the environment.  Intralytix’s concept for eco-management in food processing plants and similar establishments is to use lytic bacteriophages that specifically target a small number of selected "bad" bacteria without affecting any of the "good" bacteria.  The concept/technology provides the most gentle, environmentally-friendly, non-toxic, and safe approach for dealing with pathogenic bacteria in specific environmental settings ("eco-management"). 

One of Intralytix, Inc.’s phage preparations (ListShield™) has already received regulatory approval from the U.S. Environmental Protection Agency for the first in a line of products designed to prevent or significantly reduce bacterial contamination of food processing plants (EPA registration #74234-1).  ListShield™ is the first in a series of products developed by Intralytix, Inc. to decontaminate and protect food-processing facilities (and hence our foods) from other deadly bacterial contaminants such as Salmonella, Campylobacter and E. coli 0157:H7.  Some of the other potential areas for Intralytix’s eco-management approach using bacteriophages are listed below.

Areas of Practical Applications

Properly developed and manufactured phage preparations can be invaluable in specifically eliminating, or significantly reducing the levels of, targeted "problem" bacteria in specific environmental settings, such as:



Technology

Food Safety

Environmental Sanitation

Veterinary Applications

Human Therapeutics

Probiotics